Synthroid Uses, Dosage & Side Effects

Myxedema coma is a life-threatening emergency characterized by poor circulation and hypometabolism and may result in unpredictable absorption of levothyroxine sodium from the gastrointestinal tract. Use of oral thyroid hormone drug products is not recommended to treat myxedema coma. Administer thyroid hormone products formulated for intravenous administration to treat myxedema coma. In adult patients with primary hypothyroidism, monitor serum TSH levels after an interval of 6 to 8 weeks after any change in dosage. In patients on a stable and appropriate replacement dosage, evaluate clinical and biochemical response every 6 to 12 months and whenever there is a change in the patient’s clinical status. Assess the adequacy of therapy by periodic assessment of laboratory tests and clinical evaluation.

What other drugs will affect Synthroid?

Absorption of orally administered T4 from the gastrointestinal tract ranges from 40% to 80%. The majority of the SYNTHROID dose is absorbed from the jejunum and upper ileum. The relative bioavailability of SYNTHROID tablets, compared to an equal nominal dose of oral levothyroxine sodium solution, is approximately 93%. T4 absorption is increased by fasting, and decreased in malabsorption syndromes and by certain foods such as soybeans. In addition, many drugs and foods affect T4 absorption see DRUG INTERACTIONS.

Dosage Forms And Strengths

The recommended starting daily dosage of SYNTHROID in adults with primary, secondary, or tertiary hypothyroidism is based on age and comorbid cardiac conditions, as described in Table 1. For patients at risk of atrial fibrillation or patients with underlying cardiac disease, start with a lower dosage and titrate the dosage more slowly to avoid exacerbation of cardiac symptoms. Dosage titration is based on serum TSH or free-T4 see Important Considerations For Dosing. Synthroid is prescribed in tablets that range from 25 to 300 mcg in strength and is usually taken once a day with a full glass of water (about 8 ounces) 30 to 60 minutes before breakfast for best adsorption into the body. Children can take the medicine if the tablet is crushed and put into about 1 to 2 teaspoons of water; do not store or delay giving this crushed pill suspension.

However, you may not be able to take this medicine if you have certain medical conditions. The major pathway of thyroid hormone metabolism is through sequential deiodination. Approximately 80% of circulating T3 is derived from peripheral T4 by monodeiodination.

Notify your doctor if you experience serious side effects of Synthroid including rapid heartbeat, fluttering in your chest, or chest pain. Get medical help right away, if you have any of the symptoms listed above. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Synthroid only for the indication prescribed.

Levothyroxine is generally continued for life in these patients see WARNINGS AND PRECAUTIONS. SYNTHROID increases the response to oral anticoagulant therapy. Therefore, a decrease in the dose of anticoagulant may be warranted with correction of the hypothyroid state or when the SYNTHROID dose is increased.

Levothyroxine: Công dụng, liều dùng và lưu ý tác dụng phụ

Monitor serum free-T4 levels and maintain in the upper half of the normal range in these patients. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using. Levothroid is used for hashimoto’s disease, hypothyroidism, after thyroid removal, synthroid pancreatitis myxedema coma … Eltroxin is used for hashimoto’s disease, hypothyroidism, after thyroid removal, myxedema coma …

Thyroid hormones, including SYNTHROID, either alone or with other therapeutic agents, should not be used for the treatment of obesity or for weight loss. In euthyroid patients, doses within the range of daily hormonal requirements are ineffective for weight reduction. Larger doses may produce serious or even life-threatening manifestationsof toxicity, particularly when given in association with sympathomimetic amines such as those used for their anorectic effects.

• Because some preparations of the drug may contain iodine or lactose, patients should tell their doctors about such allergies or reactions to these components.
• Cerebral embolism, shock, coma, and death have been reported.
• Our Synthroid Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
• Consumption of certain foods may affect SYNTHROID absorption thereby necessitating adjustments in dosing see DOSAGE AND ADMINISTRATION.
• This is not a complete list of side effects and others may occur.

Adverse Reactions In Pediatric Patients

Armour Thyroid is used for hashimoto’s disease, hypothyroidism, after thyroid removal, thyroid … Your child’s dose needs may change if the child gains or loses weight. SYNTHROID is contraindicated in patients with uncorrected adrenal insufficiency see WARNINGS AND PRECAUTIONS.

If cardiac symptoms develop or worsen, reduce the SYNTHROID dose or withhold for one week and restart at a lower dose. Seizures have been reported rarely with the institution of levothyroxine therapy. SYNTHROID tablets should be protected from light and moisture. The peak therapeutic effect of a given dose of SYNTHROID may not be attained for 4 to 6 weeks. Administer SYNTHROID at least 4 hours before or after drugs known to interfere with SYNTHROID absorption see DRUG INTERACTIONS. Euthyrox (levothyroxine) is used to treat hypothyroidism and to treat or prevent goiter.